Types Of Skin Cancer Biography
Source(google.com.pk)Skin cancers are named for the type of cells that become malignant (cancer). The three most common types are:
Melanoma: Melanoma begins in melanocytes (pigment cells). Most melanocytes are in the skin. See the picture of a melanocyte and other skin cells.
Melanoma can occur on any skin surface. In men, it's often found on the skin on the head, on the neck, or between the shoulders and the hips. In women, it's often found on the skin on the lower legs or between the shoulders and the hips.
Melanoma is rare in people with dark skin. When it does develop in people with dark skin, it's usually found under the fingernails, under the toenails, on the palms of the hands, or on the soles of the feet.
Basal cell skin cancer: Basal cell skin cancer begins in the basal cell layer of the skin. It usually occurs in places that have been in the sun. For example, the face is the most common place to find basal cell skin cancer.
In people with fair skin, basal cell skin cancer is the most common type of skin cancer.
Squamous cell skin cancer: Squamous cell skin cancer begins in squamous cells. In people with dark skin, squamous cell skin cancer is the most common type of skin cancer, and it's usually found in places that are not in the sun, such as the legs or feet.
However, in people with fair skin, squamous cell skin cancer usually occurs on parts of the skin that have been in the sun, such as the head, face, ears, and neck.
Unlike moles, skin cancer can invade the normal tissue nearby. Also, skin cancer can spread throughout the body. Melanoma is more likely than other skin cancers to spread to other parts of the body. Squamous cell skin cancer sometimes spreads to other parts of the body, but basal cell skin cancer rarely does.
When skin cancer cells do spread, they break away from the original growth and enter blood vessels or lymph vessels. The cancer cells may be found in nearby lymph nodes. The cancer cells can also spread to other tissues and attach there to form new tumors that may damage those tissues.
The spread of cancer is called metastasis. See the Staging section for information about skin cancer that has spread.
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Actinic Keratosis: Precursor to Squamous Cell Carcinoma
Rough, red or pink scaly patches on sun-exposed areas of the skin,usually <0.5cm in diameter
Precurser lesion for squamous cell carcinoma (Squamous Cell Carcinoma)
Up to 1% of these lesions can develop into a Squamous Cell Carcinoma
See actinic keratosis photos and patient information
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Basal Cell Carcinoma :
Raised, pink, waxy bumps that may bleed following minor injury
May have superficial blood vessels and a central depression
Locally invasive
Rarely metastasizes
Organ transplant recipients have a 10-fold higher risk for Basal Cell Carcinoma compared to the general population(2)
See basal cell carcinoma photos and patient information.
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Melanoma:
Neoplasm of pigment (melanin) producing cells
Brown or black skin lesion with irregularities in symmetry, border and coloration
Prognosis dependent on depth of invasion
~100,000 new cases of melanoma are diagnosed in the United States each year
Only 4% of diagnosed skin cancer, but 77% of skin cancer related deaths
Organ transplant recipients have a 3 to 4-fold higher risk for melanoma compared to general population(12)
Melanoma accounts for ~6% of post transplant skin cancers in adult transplant recipients(13)
Melanoma accounts for 12-15% of post transplant skin cancers in pediatric organ transplant recipients(13)
Transplant recipients with a pre-transplant history of melanoma have a high risk of recurrence (~20%)(14)
See melanoma photos and patient information.
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Kaposi's Sarcoma
Kaposi's Sarcoma
Click on the image for
a larger view
Kaposi's Sarcoma (KS):
Rare, cancer of the cells that line blood vessels (endothelial cells)
Clinically: brownish-red to blue colored skin lesions found most frequently on legs and feet
Caused by Human Herpes Virus 8 (HHV-8) which causes the cells that line blood vessels (endothelial cells) to become cancerous in the setting of profound and prolonged immunosuppression
Typically occurs in patients of Middle Eastern, Jewish, Mediterranean or African descent where HHV-8 in endemic
Two main forms of KS exist
Cutaneous/Mucocutaneous
Most common form than occurs in adult transplant patients(1)
Most adult cases occur within 1-2 years following transplantation
Treatments include reduction in immunosuppression and rapamycin(15)
Visceral
Most common form that occurs in pediatric transplant patients(13)
Most pediatric cases occur while the patient is < 18 years old
KS tumors can affect the gastrointestinal system, lymph nodes and lungs
The visceral form is considered more serious than the cutaneous/mucocutaneous form
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Squamous Cell Carcinoma:
Most common skin cancer affecting transplant patientss
Dull red, rough, scaly raised skin lesions
Occur most frequently on sun exposed areas (head, neck, ears, lips, back of the hands and forearms)
Sites particularly associated with elevated risk for recurrence or metastasis include: ear, lip/perioral, nose, periorbital, genitalia
Most common skin cancer that occurs in pediatric and adult transplant recipients
Ratio of Squamous Cell Carcinoma:Basal Cell Carcinoma = 3:1, opposite to the general population
Squamous Cell Carcinoma tumors can grow very rapidly
Mutiple cancers can occur simultaneously
Squamous Cell Carcinoma tends to be more invasive and more aggressive in transplant patients
Organ transplant recipients have a 65-fold higher risk for Squamous Cell Carcinoma and 20-fold higher risk for Squamous Cell Carcinoma of the lip compared to the general population(16)
Adult transplant patients tend to develop Squamous Cell Carcinoma 5-7 years following transplant
Pediatric transplant patients (patients who received their transplants before the age of 18) tend to develop Squamous Cell Carcinoma an average of 10 years following transplant (13)
Pediatric transplant patient have higher risk for Squamous Cell Carcinoma of the lip compared to adult transplant patients
Local recurrence rate ~13% in adult transplant patients(17, 18)
Metastatic rate ~2% in general population
5-7% in adult organ transplant patients(19)
13% in pediatric organ transplant patients (13)
Current Guidelines suggest Squamous Cell Carcinoma be risk stratified. Read more about these guidelines.
Types Of Skin Cancer Skin Cancer Pictures Moles Symptoms Sings On Face Spots On Nose Photos Types Pics Wallpapers Pics
Types Of Skin Cancer Skin Cancer Pictures Moles Symptoms Sings On Face Spots On Nose Photos Types Pics Wallpapers Pics
Types Of Skin Cancer Skin Cancer Pictures Moles Symptoms Sings On Face Spots On Nose Photos Types Pics Wallpapers Pics
Types Of Skin Cancer Skin Cancer Pictures Moles Symptoms Sings On Face Spots On Nose Photos Types Pics Wallpapers Pics
Types Of Skin Cancer Skin Cancer Pictures Moles Symptoms Sings On Face Spots On Nose Photos Types Pics Wallpapers Pics
Types Of Skin Cancer Skin Cancer Pictures Moles Symptoms Sings On Face Spots On Nose Photos Types Pics Wallpapers Pics
Types Of Skin Cancer Skin Cancer Pictures Moles Symptoms Sings On Face Spots On Nose Photos Types Pics Wallpapers Pics
Types Of Skin Cancer Skin Cancer Pictures Moles Symptoms Sings On Face Spots On Nose Photos Types Pics Wallpapers Pics
Types Of Skin Cancer Skin Cancer Pictures Moles Symptoms Sings On Face Spots On Nose Photos Types Pics Wallpapers Pics
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